The FY24 PRCRP Idea Award supports innovative, untested, high-risk/potentially high-reward concepts, theories, paradigms, and/or basic cancer research. The advancement of knowledge in cancer research, patient care, and/or treatment options in the MHS is critical to active-duty Service Members, Veterans, other military beneficiaries, and the American public.The intention of the Idea Award is innovative basic research that may introduce a new paradigm, challenge existing paradigms, look at existing problems from new perspectives, or exhibit other highly creative qualities. The Idea Award is not intended to support a logical progression of an already established research project in a laboratory. Incremental advances, the next logical step, or switching a model system from one cancer to another cancer are not considered innovative. The proposed research project should include a well-formulated, testable hypothesis based on strong scientific rationale and study design and generate robust preliminary data that can be used as a foundation for future research projects.Inclusion of preliminary data is discouraged. This award is not intended to support ongoing research in the applicants laboratory; therefore, inclusion of preliminary data is not consistent with the exploratory nature of this award.It is the responsibility of the Principal Investigator (PI) to select the funding opportunity that is most appropriate for the research proposed. Advanced research with robust preliminary data is more appropriate for the FY24 PRCRP Impact Award (HT942524PRCRPIPA).