The Established Program to Stimulate Competitive Research (EPSCoR) fulfills the mandate of the National Science Foundation (NSF) to promote scientific progress nationwide. NSF EPSCoR facilitates the establishment of partnerships among academic institutions, government, industry, and non-profit sectors that are designed to promote sustainable improvements in the research infrastructure, Research and Development (R) capacity, and R competitiveness of EPSCoR-eligible jurisdictions (i.e., states, territories, and commonwealths). The E-RISE RII program supports the incubation of research teams and products in a scientific topical area that links to research priorities identified in the submitting jurisdictions approved Science and Technology (S) Plan. E-RISE RII invites innovative proposals that will lead to development and implementation of sustainable broad networks of individuals, institutions, and organizations that will transform the science, technology, engineering and mathematics (STEM) research capacity and competitiveness in a jurisdiction within the chosen field of research. E-RISE RII projects must be designed to incubate (i) areas of research capacity building within a chosen research topic; (ii) development of a skilled workforce that is relevant to the project and its outcomes; (iii) promotion of diversity, equity, access, and a culture of inclusion of different types of academic institutions (see below) and non-academic sectors (e.g., industry and government); (iv) integration of the research with societal impacts in a timebound manner; and (v) sustainability of a clear pathway towards preserving the resulting research incubator's team and products beyond E-RISE RII funding.