The Department of States Office of the Nonproliferation and Disarmament Fund (ISN/NDF) is pleased to announce an open competition for assistance awards through this Notice of Funding Opportunity (NOFO). ISN/NDF invites non-profit/non-governmental organizations, international organizations, educational institutions, US federal agencies and institutions, and for-profit organizations to submit proposals for projects that will advance the mission of NDFs biological threat reduction special project. Proposals may not exceed the total availability of funds under this NOFO. ISN/NDF will only consider proposals that fully address all NDFs lines of effort, which are further described in Section II, in their entirety.