The overarching goal of the supported research projects will be to determine neural and cognitive mechanisms that underlie the relationship between social cognition/behavior and the SUD trajectory. The purpose of this notice of funding opportunity (NOFO) is to solicit applications proposing mechanistic, transdisciplinary research on social behavior and its relationships with the onset, trajectory, and impact of Substance Use Disorders (SUDs) and comorbidities.

This NOFO is intended to support basic or early translational studies that may, but need not, be considered NIH clinical trials; this may include mechanistic clinical trials, observational studies, or secondary analysis of human data. Clinical trials supported by this funding opportunity are limited to mechanistic clinical trials. A mechanistic clinical trial is designed to understand a biological or behavioral process, the pathophysiology of a disease, biomarkers for a disease or response to treatment, or the mechanism of action of an intervention. It is not designed to test the safety or demonstrate the efficacy/effectiveness of an intervention. This NOFO is not intended to support studies designed to test the safety or demonstrate the efficacy of an intervention. Application budgets are not limited but need to reflect the actual needs of the proposed project.