The NIH Multidisciplinary Studies of HIV/AIDS and Aging (R01 Clinical Trial Optional) program invites research applications that explore the intersection of HIV and aging. The initiative aims to enhance understanding of biological, clinical, and socio-behavioral aspects of aging as they relate to HIV infection and its treatment. It also seeks to improve testing, prevention, treatment, and management of HIV-related comorbidities, co-infections, and complications across diverse populations and cultural contexts. Projects must align with the HIV/AIDS Research Priorities outlined by NIH’s Office of AIDS Research.

This funding opportunity is open to a wide range of applicants, including higher education institutions, nonprofits, government entities, and foreign organizations. Applications are particularly encouraged from minority-serving institutions, such as Historically Black Colleges and Universities and Tribal Colleges. The award budget is not limited but must reflect the project’s actual needs, with a maximum project period of five years. Projects may include clinical trials and are evaluated for their significance, innovation, rigor, and feasibility. Eligible applicants must comply with NIH registration requirements, including registration in the System for Award Management (SAM) and eRA Commons.

Research areas of interest include the interaction of aging and HIV in relation to cognitive, physical, and mental health, as well as comorbidities like cardiovascular disease, osteoporosis, and neurodegenerative disorders. Studies are encouraged to address outcomes relevant to geriatric medicine and leverage existing NIH-funded resources where feasible. Specific NIH Institutes and Centers, such as the NIA, NIMH, and NIDA, support projects focused on the unique needs of older adults living with HIV, including those experiencing substance use disorders, mental health issues, or cancer.

Applications must be submitted electronically via NIH’s ASSIST system or Grants.gov. Required materials include a detailed research plan, budget, and data-sharing plan. The application process adheres to NIH's peer review standards, focusing on scientific merit and alignment with program priorities. Deadlines for submissions are May 7, 2025, September 7, 2025, and January 7, 2026, with subsequent cycles through 2027. Letters of intent are not required.

The program emphasizes diversity and inclusion, encouraging applications that address health disparities, promote gender and racial equity, and improve the quality of life for aging individuals with HIV. Successful projects are expected to contribute to the scientific understanding of HIV and aging, drive innovation, and offer solutions that improve health outcomes in affected populations. NIH encourages early submission to allow time for addressing submission errors.