The Centers for Chemical Innovation (CCI) Program supportsresearch centersfocused on major, long-term fundamental chemical researchchallenges.CCIs that addressthese challenges will produce transformative research, lead to innovation, and attract broad scientific and public interest. CCIs are agile structures that can respond rapidly to emerging opportunities through enhanced collaborations. CCIs integrate research with strong broader impacts, including innovation, education, broadening participation, andinformal science communication. The CCI Program is a two-phase program. Both phases are described in this solicitation. Phase I CCIs receive significant resources to develop the science, management and broader impacts of a major research center before requesting Phase II funding. Satisfactory progress in Phase I is required for Phase II applications; Phase I proposals funded in FY 2024 will seek Phase II funding in FY 2027. The FY 2024 Phase I CCI competition is open to projects in all fields supported by the Division of Chemistry, and must have scientific focus and the potential for transformative impact in chemistry.The NSF Division of Chemistry particularly encourages fundamental chemistry projects aligned with articulated budget priorities, including Advanced Manufacturing, Artificial Intelligence, Semiconductor Research, Biotechnology, Climate Research and Sustainability, Clean Energy, and Quantum Information Science. The FY 2024 Phase II CCI competition is open to projects funded as Phase I awards in FY 2021. The FY 2025 Phase II CCI competition is open to projects funded as Phase I awards in FY 2022 as well as renewals of Phase II proposals funded in FY 2020.