Scott R Mackenzie Foundation Inc

PO BOX 550750 - JACKSONVILLE - FL 322550750, Florida

Latest Filing: 2023

Total Assets: $14.87M

Total Giving: $1.01M

Grants: 6

Median Grant: $149,250

SCOTT R MACKENZIE FOUNDATION INC is a selective grantmaker that only funds pre-selected organizations, distributing $1M through 6 grants annually.

2023 Summary

$14.87M

Total Assets

$1.01M

Funding Awarded

Grants Given

$149,250

Median Grant

$400,000

Largest Grant

$9,763

Smallest Grant

2023 Recipients

Recipient	Award	Location	Purpose
Mount Desert Island Biological Laboratory	$400,000	Bar Harbor, MAINE	The Benefactor Desires That Grantee Shall Use The Gift To Prevent Organ Complications In Diabetic Patients. High Glucose Levels Lead To The Pathalogical Changes In The Vasculature Of Different Organs Such As The Heart, Kidney, Eye And Peripheral Circulation. The Focus Is The Microcirculation Of The Kidney. The Endothelial Cell Surface Is Covered With A Layer Of Glycocalyx. The Glycocalyx Is Very Important For The Health Of The Vascular Wall And Regulates Central Mechanisms Such As Metabolism, Inflammation, Blood Pressure, Etc. We Will Test The Hypothesis That Recombinant Hpa2 Ameliorates Diabetic Nephropathy By Maintaining A Functional Heparan Sulfate Glycocalyx On Endothelial Cells And Monocytes.
University Of Arizona	$175,006	Tucson, ARIZONA	The Benefactor Desires That Grantee Shall Use The Gift To Improve The Diagnosis And Treatment Of Atrial Fibrillation. To Develop Patient Specific Targeted Next Generation Gene Sequencing For Predicting And Diagnosing Atrial Fibrillation And Establish A Patient Specific Stem Cell Platform For Developing Precision Medicine Based Treatments.
University Of Florida Foundation	$150,000	Gainesville, FLORIDA	The Benefactor Desires That Grantee Shall Use The Gift To Broaden The Discovery Of New Pancreatic Cancer Biomarkers Through Genomic Sequencing. By Sequencing Tumor And Normal Samples From Our Patients, We Can Determine Novel Cancer Drivers Including Mutations, Fusions, And Gene Expression Alterations That Drive These Cancers. New Biomarkers Will Introduce New Potential Targets For Treatment And Early Detections.
Israel Cancer Research Fund	$148,500	New York, NEW YORK	The Benefactor Desires That Grantee Shall Use The Gift To Ask How Dna Repair Is Orchestrated Despite The Packaging Of Dna Into Chromatin. Swi/Snf Proteins Establish And Maintain Chromatin Structure. Subunits Of Swi/Snf Proteins Are Mutated In 20% Of Cancers, Implicating Them In Carcinogenesis, And Making Them Attractive Candidates For Cancer Specific And Selective Therapies. Dr. Adar Expects To Establish That Swi/Snf Remodelers Facilitate Specific Steps In Nucleotide Excision Repair (Ner) In Chromatin Templates, And That Cancer Associated Mutants Are Deficient In This Function. This New Understanding Of Swi/Snf Functions Can Then Be Leveraged To Design New Cancer Diagnostics And Chemotherapeutics.
University Of Florida Foundation	$125,000	Gainesville, FLORIDA	The Benefactor Desires That Grantee Shall Use The Gift To Assess Potential Drug Interactions Between Cangrelor And Novel P2 Y12 Inhibitors And Evaluate The Impact Of Receptor Expression On Their Findings.
Mayo Clinic	$9,763	Jacksonville, FLORIDA	The Benefactor Desires That Grantee Shall Use This Gift To Support The Tapestry Study.

$148,500

$400,000

State

Total

ME

Maine

$400,000
FL

Florida

$284,763
AZ

Arizona

$175,006
NY

New York

$148,500

Contacts

Name	Phone	Title
SCOTT R MACKENZIE	8558166858	DIRECTOR
SCOTT MACKENZIE		Signing Officer

Historical Financials

Year	Total Assets	Total Giving	Grants	Median Grant	Max Grant	Min Grant
2023	$14,866,228	$1,008,269	6	$149,250	$400,000	$9,763
2021	$14,357,687	$939,383	6	$126,724	$350,000	$60,934
2020	$17,006,268	$825,000	4	$187,500	$400,000	$50,000
2019	$17,743,339	$946,691	3	$330,000	$336,691	$280,000
2018	$18,030,101	$1,190,203	5	$282,000	$350,000	$125,000